Robert W Brueggemeier Selected Research

Aromatase (CYP19)

2/2012	SPANosomes as delivery vehicles for small interfering RNA (siRNA).
8/2011	Comparison of increased aromatase versus ERα in the generation of mammary hyperplasia and cancer.
5/2010	Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7alpha-APTADD to breast cancer cells.
2/2010	Selective regulation of aromatase expression for drug discovery.
7/2008	Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.
3/2008	Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: synthesis, biological evaluation, and ligand-based pharmacophore identification.
3/2008	4-Hydroxyphenylretinamide (4HPR) derivatives regulate aromatase activity and expression in breast cancer cells.
1/2008	Suppression of aromatase in human breast cells by a cyclooxygenase-2 inhibitor and its analog involves multiple mechanisms independent of cyclooxygenase-2 inhibition.
8/2007	Aromatase and COX in breast cancer: enzyme inhibitors and beyond.
4/2007	Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells.

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Robert W Brueggemeier Research Topics

Disease

44	Breast Neoplasms (Breast Cancer) 04/2019 - 02/2002
16	Neoplasms (Cancer) 01/2017 - 05/2002
3	Carcinoma (Carcinomatosis) 08/2011 - 04/2002
2	Adenocarcinoma 01/2003 - 02/2002
1	Triple Negative Breast Neoplasms 01/2017
1	Drug-Related Side Effects and Adverse Reactions 01/2017
1	Hyperplasia 08/2011
1	Noninfiltrating Intraductal Carcinoma (DCIS) 08/2011
1	Cardiovascular Diseases (Cardiovascular Disease) 08/2011
1	Dehydration (Water Stress) 04/2005

Drug/Important Bio-Agent (IBA)

25	Aromatase (CYP19)IBA 02/2012 - 02/2002
21	Estrogens (Estrogen)FDA Link 08/2011 - 02/2002
16	Hormones (Hormone)IBA 02/2010 - 04/2002
13	Estrogen ReceptorsIBA 04/2019 - 05/2002
8	EnzymesIBA 02/2010 - 06/2003
7	Aromatase InhibitorsIBA 05/2010 - 04/2002
5	Celecoxib (Celebrex)FDA Link 04/2019 - 05/2005
5	Biological ProductsIBA 01/2017 - 04/2007
4	Tamoxifen FDA LinkGeneric 04/2019 - 05/2005
4	exemestane (Aromasin)FDA Link 08/2011 - 04/2002
4	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 08/2007 - 09/2003
4	ProstaglandinsIBA 05/2006 - 02/2002
3	Phosphatidylinositols (Phosphatidylinositol)IBA 04/2019 - 11/2006
3	OSU 03012IBA 04/2019 - 11/2006
3	keratinocyte growth factor receptorIBA 01/2015 - 11/2007
3	Tyrosine Kinase InhibitorsIBA 01/2015 - 11/2007
3	Small Interfering RNA (siRNA)IBA 01/2013 - 02/2012
3	Messenger RNA (mRNA)IBA 02/2010 - 05/2005
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 05/2008 - 02/2002
3	nimesulide (Aulin)IBA 05/2008 - 05/2005
3	AndrogensIBA 03/2008 - 07/2004
3	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 08/2007 - 05/2002
3	Prostaglandins EIBA 05/2006 - 02/2002
3	Estrogen Receptor Modulators (Antiestrogen)IBA 02/2004 - 04/2002
2	Protein Kinases (Protein Kinase)IBA 04/2019 - 04/2008
2	Trastuzumab (Herceptin)FDA Link 01/2017 - 11/2006
2	Pharmaceutical PreparationsIBA 01/2017 - 02/2010
2	Fibroblast Growth Factor 7 FDA Link 01/2015 - 12/2010
2	LipidsIBA 07/2012 - 05/2010
2	Green Fluorescent ProteinsIBA 07/2012 - 02/2012
2	Antineoplastic Agents (Antineoplastics)IBA 12/2010 - 11/2007
2	LigandsIBA 03/2008 - 09/2003
2	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA 01/2008 - 05/2005
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 05/2006 - 05/2005
2	Cyclooxygenase InhibitorsIBA 05/2006 - 05/2005
2	Anastrozole (Arimidex)FDA LinkGeneric 02/2004 - 04/2002
2	Letrozole (Femara)FDA LinkGeneric 02/2004 - 04/2002
2	8-Hydroxy-2'-DeoxyguanosineIBA 01/2004 - 05/2002
1	Monoclonal AntibodiesIBA 01/2017
1	Sirolimus (Rapamycin)FDA Link 01/2017
1	Liposomes (Liposome)IBA 01/2017
1	Phosphotransferases (Kinase)IBA 01/2017
1	Human Serum Albumin FDA LinkGeneric 01/2013
1	Lipid NanoparticlesIBA 01/2013
1	erucylphosphocholineIBA 07/2012
1	Progesterone FDA LinkGeneric 08/2011
1	Transferrin (beta 2 Transferrin)IBA 05/2010
1	mangostinIBA 07/2008
1	XanthonesIBA 07/2008
1	Proteins (Proteins, Gene)FDA Link 04/2008
1	FenretinideIBA 03/2008
1	ColforsinIBA 01/2008
1	IsoflavonesIBA 01/2008
1	Phorbol EstersIBA 01/2008
1	IGF Type 1 Receptor (IGF 1 Receptor)IBA 11/2006
1	Cyclic AMP (AMP, Cyclic)IBA 05/2006
1	Protein Isoforms (Isoforms)IBA 05/2006
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 04/2006
1	Piroxicam (Feldene)FDA LinkGeneric 05/2005
1	1- ((4- methylsulfonyl)phenyl)- 3- trifluoromethyl- 5- (4- fluorophenyl)pyrazoleIBA 05/2005
1	Ibuprofen (Motrin)FDA LinkGeneric 05/2005
1	Indomethacin (Indometacin)FDA LinkGeneric 05/2005
1	Niflumic AcidIBA 05/2005
1	AldehydesIBA 04/2005
1	Troglitazone (Rezulin)FDA Link 04/2005
1	PPAR gammaIBA 04/2005
1	Cyclin D1IBA 04/2005
1	ThiazolidinedionesIBA 04/2005
1	ciglitazoneIBA 04/2005
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 07/2004
1	AntioxidantsIBA 01/2004
1	Dinoprostone (PGE2)FDA Link 09/2003
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 09/2003
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 01/2003
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2003
1	Estrogen Receptor alphaIBA 01/2003
1	gamma-glutamylcysteineIBA 05/2002
1	Peptidyl Transferases (Peptidyltransferase)IBA 05/2002
1	Glutathione (Reduced Glutathione)IBA 05/2002
1	buthionineIBA 05/2002
1	Cyclooxygenase 1IBA 02/2002
1	Acetates (Acetic Acid Esters)FDA Link 02/2002
1	Epidermal Growth Factor (EGF)IBA 02/2002
1	phorbolIBA 02/2002
1	Transforming Growth Factor beta (TGF-beta)IBA 02/2002

Therapy/Procedure

11	Therapeutics 01/2017 - 04/2002
2	Chemoprevention 07/2008 - 11/2007
2	Aftercare (After-Treatment) 10/2006 - 05/2005